5/19/2023 0 Comments AdrenocorticalHowever, benign, clinically occult adrenal adenomas, adrenal “incidentalomas,” are encountered frequently by abdominal imaging performed for unrelated indications. Tumor morphology is a better predictor of metastatic risk in ACCa than current immunohistochemistry-detected cell cycle regulatory and proliferation–associated proteins.Īdrenocortical carcinoma is a highly aggressive, rare endocrine malignancy. Tumor cell proliferation (Ki-67) correlates with mitotic activity and morphologic index. Well-established histopathologic criteria and Ki-67 can specifically distinguish ACCAd from ACCa. Tumor necrosis, atypical mitoses, and >1 mitosis per 50 high-power fields were factors that were highly specific for ACCa ( P 5 mitoses per 50 high-power fields, sinusoidal invasion, histologic index of >5, and presence of more than two unfavorable molecular markers were associated significantly with metastasis in ACCa. Expression profiles of p53, mdm-2, p21, Bcl-2, cyclin D1, p27, and Ki-67 were investigated by immunohistochemistry and correlated with histopathology and patient outcome using standard statistical methodology. Paraffin-embedded tissue cores of ACAd ( n = 33) and ACCa ( n = 38) were arrayed in triplicate on tissue microarrays. A critical histopathological review (mean, 11 slides per patient) was conducted of 37 ACAd and 67 ACCa. We compared histomorphological features and molecular expression profiles of adrenocortical adenomas (ACAd) and carcinomas (ACCa).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |